Urinary 1-hydroxypyrene in coke oven workers relative to exposure, alcohol consumption, and metabolic enzymes
نویسندگان
چکیده
منابع مشابه
Urinary 1-hydroxypyrene in coke oven workers relative to exposure, alcohol consumption, and metabolic enzymes.
OBJECTIVES To investigate the influence of personal lifestyle--such as smoking and alcohol consumption-on urinary 1-hydroxypyrene (1-OHP) concentrations in coke oven workers exposed to polycyclic aromatic hydrocarbons (PAHs) and to evaluate the association of 1-OHP concentrations with the genetic polymorphism of several metabolic enzymes including cytochrome P-450 (CYP) 1A1 and glutathione S-tr...
متن کاملSignificant positive correlation of plasma BPDE-albumin adducts to urinary 1-hydroxypyrene in coke oven workers.
OBJECTIVE To investigate the application of BPDE-albumin adducts as monitoring biomarkers for coke oven workers exposed to polycyclic aromatic hydrocarbons (PAHs) and to explore possible relationship between BPDE-albumin adducts and urinary 1-hydroxypyrene (1-OHP) levels in them. METHODS Thirty-seven coke oven workers from a coke plant and 47 controls without the occupational exposure to PAHs...
متن کاملAssociation between urinary 1-hydroxypyrene and genotoxic effects in coke oven workers.
AIMS To investigate whether current occupational exposure of coke oven workers to polycyclic aromatic hydrocarbons (PAHs) results in genotoxic effects measured in peripheral blood lymphocytes and whether these biomarkers are associated with the biomarkers of exposure. METHODS Blood and urine samples were collected immediately after a shift at the end of a working week from 50 coke oven worker...
متن کاملTemporal changes in urinary 1-hydroxypyrene concentrations in coke-oven workers.
Coke-oven workers are exposed to high concentrations of coke-oven emissions, which are comprised mainly of polycyclic aromatic hydrocarbons. We conducted a pilot study to determine the time changes in urinary 1-hydroxypyrene (1-OHP) concentrations, as a metabolite of pyrene, in coke-oven workers after exposure to a benzene-soluble fraction (BSF) of total particulates. Thirteen subjects, includi...
متن کاملUrinary 1-hydroxypyrene and 8-hydroxydeoxyguanosine levels among coke-oven workers for 2 consecutive days.
OBJECTIVES This study evaluated the levels of exposure to polycyclic aromatic hydrocarbons (PAHs) and their relationship with oxidative DNA damage among Vietnamese coke-oven workers. METHODS We collected urine from 36 coke-oven workers (exposed group) at the beginning and end of the shift on 2 consecutive days. We also collected urine from 78 medical staff (control group). Information was col...
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ژورنال
عنوان ژورنال: Occupational and Environmental Medicine
سال: 2001
ISSN: 1351-0711
DOI: 10.1136/oem.58.11.716